The mission itself matters less than the specifics of intensity level by which it is accomplished.
If you fight China, you need something which can self-escort or at least remain unseen. If you fight AfG, you need something which can SEE the enemy, over huge expanses of great-wide-nothin'.
With that as a precondition:
An F-22 can drop 8 GBU-39s which is the equal of an entire flight of F-16s and both would be considered 'superior bombers' to say an A-6E or F-111 dedicated interdictor, simply because the target area terminal defenses and medium/high altitude delivery profiles both make standoff attack with significant (burner) EM or signature (RFLO) performance more important than things like nominal bombload for radius where dedicated aircraft tend to excel. Transports are worthless unless they are bouth in sufficient numbers to replace and/or augment sea lift. At best they can serve as a surge capability for munitions and critical spares. Helicopters of all kinds never leave the operating envelope of the cheapest trashfire threats out there. VTOLs in general pay too high a penalty in operating costs (twice the moving-widgets as cyclative fatigue drivers) and useful mission volume. The F-35B will be lucky to have 12,000lbs of fuel and a 4,000lb payload with a running takeoff of 400ft and a VTOL recovery after significant burndown on (naval) reserves. All of which translates to a sub-400nm radius, little better than the Harrier and vastly less than the dedicated (650-700nm) CTOL and CVTOL versions whose 'safety' comes from both larger numbers and greater standoff against TBMs and tactical rockets. Of all these, the MOST effective however will always be the aircraft which is _on station_ to pick up the target and engage it with appropriate weapons systems. Since single round hits are usually lethal on all but the hardest targets, and because ISR is implicit to the superior sensor fit as well as range+loiter of the Predator/Reaper combination, I would generally pick a dedicated UAV/UCAV over a 'multirole' type. Because anything which is LO'd invisible and supported by offboard targeting can be a fighter with a digital uplink AMRAAM aboard. But the manned jet is only going to be there as long as the pilot can stand the ache of his steel seat and the eyes-gone-funny fatigue of coming home to land safely. Which is always (6-8hrs, only 40 minutes of which is in the combat area) going to be less than a third of what an optimized unmanned platform can achieve.
uhh. You forgot about cargo aircraft. I'm my opinion the C-130 is the best military aircraft and not because I work on them. There are SO MANY variations of the airframe that there is a C-130 for nearly every job. AC-130H/U gunships to blow stuff up. MC-130E/H for the sneaky squirrel stuff. HC-130P for refueling. They even carry cargo TOO!