depends on you body structure. If you're 4'-11" and changing your body weight 70-80lbs then yes it will matter, on the other hand, if you're 9'-10" then it wont matter. The point is, a little change in body weight should not affect most areas tattooed, alot of change, up or down, will affect how a tattoo looks, there again depends on the detail of the piece. Can I ask why you would dramatically change you weight by so much?